2VXT
Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab
Summary for 2VXT
Entry DOI | 10.2210/pdb2vxt/pdb |
Related | 1J0S 2VXU 2VXV |
Descriptor | MURINE IGG 125-2H, INTERLEUKIN-18, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | fab, il-18, secreted, cytokine, autoimmunity, glycoprotein, th1/th2 cells, immunoglobulin domain, immunoglobulin v region |
Biological source | MUS MUSCULUS (MOUSE) More |
Total number of polymer chains | 3 |
Total formula weight | 65092.66 |
Authors | Argiriadi, M.A.,Xiang, T.,Wu, C.,Ghayur, T.,Borhani, D.W. (deposition date: 2008-07-10, release date: 2009-06-23, Last modification date: 2023-12-13) |
Primary citation | Argiriadi, M.A.,Xiang, T.,Wu, C.,Ghayur, T.,Borhani, D.W. Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. J.Biol.Chem., 284:24478-, 2009 Cited by PubMed: 19553661DOI: 10.1074/JBC.M109.023887 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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