2VQQ
Structure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor
Summary for 2VQQ
Entry DOI | 10.2210/pdb2vqq/pdb |
Related | 2VQJ 2VQM 2VQO 2VQV 2VQW |
Descriptor | HISTONE DEACETYLASE 4, SULFATE ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | inhibitor, repressor, chromatin, coiled coil, histone deacetylase, transcription regulation, ubl conjugation, chromatin regulator, polymorphism, transcription, phosphoprotein, hdac, zinc, hdaci, nucleus, hydrolase, cytoplasm |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: P56524 |
Total number of polymer chains | 2 |
Total formula weight | 90248.76 |
Authors | Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. (deposition date: 2008-03-18, release date: 2008-07-08, Last modification date: 2023-12-13) |
Primary citation | Bottomley, M.J.,Lo Surdo, P.,Di Giovine, P.,Cirillo, A.,Scarpelli, R.,Ferrigno, F.,Jones, P.,Neddermann, P.,De Francesco, R.,Steinkuhler, C.,Gallinari, P.,Carfi, A. Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain. J.Biol.Chem., 283:26694-, 2008 Cited by PubMed: 18614528DOI: 10.1074/JBC.M803514200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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