2VKV

TetR (BD) variant L17G with reverse phenotype

2VKV の概要

• エントリーDOI: 10.2210/pdb2vkv/pdb
• 関連するPDBエントリー: 1A6I 1BJ0 1BJY 1BJZ 1DU7 1ORK 1QPI 2TCT 2TRT 2VKE
• 分子名称: TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D, 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: transcription, transcription regulation, disorder to order mechanism, antibiotic resistance, helix-turn-helix motif, bacterial repressor, anhydrotetracycline, metal-binding, reverse phenotype, tetr, plasmid, repressor, magnesium, dna-binding
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23824.53

構造登録者

Resch, M.,Striegl, H.,Henssler, E.M.,Sevvana, M.,Egerer-Sieber, C.,Schiltz, E.,Hillen, W.,Muller, Y.A. (登録日: 2008-01-02, 公開日: 2008-07-08, 最終更新日: 2023-12-13)

• 主引用文献: Resch, M.,Striegl, H.,Henssler, E.M.,Sevvana, M.,Egerer-Sieber, C.,Schiltz, E.,Hillen, W.,Muller, Y.A.; A Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr.; Nucleic Acids Res., 36:4390-, 2008; PubMed: 18587152; DOI: 10.1093/NAR/GKN400

実験手法

X-RAY DIFFRACTION (1.74 Å)