2VKU

4,4'-Dihydroxybenzophenone Mimics Sterol Substrate in the Binding Site of Sterol 14alpha-Demethylase (CYP51) in the X-ray Structure of the Complex

2VKU の概要

• エントリーDOI: 10.2210/pdb2vku/pdb
• 関連するPDBエントリー: 1E9X 1EA1 1H5Z 1U13 1X8V 2BZ9 2CI0 2CIB
• 分子名称: CYTOCHROME P450 51, bis(4-hydroxyphenyl)methanone, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: steroid biosynthesis, cyp51-4, cytoplasm, alpha-beta, heme co-factor, lipid synthesis, sterol biosynthesis, 4'-dihydroxybenzophenone complex, nadp, iron, heme, monooxygenase, metal-binding, oxidoreductase
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53527.02

構造登録者

Eddine, A.N.,von Kries, J.P.,Podust, M.V.,Podust, L.M. (登録日: 2007-12-29, 公開日: 2008-03-25, 最終更新日: 2023-12-13)

• 主引用文献: Eddine, A.N.,P Von Kries, J.,Podust, M.V.,Warrier, T.,Kaufmann, S.H.E.,Podust, L.M.; X-Ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14Alpha-Demethylase (Cyp51); J.Biol.Chem., 283:15152-, 2008; PubMed: 18367444; DOI: 10.1074/JBC.M801145200

実験手法

X-RAY DIFFRACTION (1.95 Å)