2VJ2
Human Jagged-1, domains DSL and EGFs1-3
Summary for 2VJ2
Entry DOI | 10.2210/pdb2vj2/pdb |
Related | 2CAO |
Descriptor | JAGGED-1, D-MALATE (3 entities in total) |
Functional Keywords | signalling, polymorphism, glycoprotein, extracellular, developmental protein, notch signaling pathway, egf, dsl, notch, jagged, calcium, membrane, protein-binding, transmembrane, egf-like domain, disease mutation, protein binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Membrane; Single-pass type I membrane protein: P78504 |
Total number of polymer chains | 2 |
Total formula weight | 37796.26 |
Authors | Johnson, S.,Cordle, J.,Tay, J.Z.,Roversi, P.,Handford, P.A.,Lea, S.M. (deposition date: 2007-12-06, release date: 2008-07-29, Last modification date: 2011-07-13) |
Primary citation | Cordle, J.,Johnson, S.,Tay, J.Z.,Roversi, P.,Wilkin, M.B.,De Madrid, B.H.,Shimizu, H.,Jensen, S.,Whiteman, P.,Jin, B.,Redfield, C.,Baron, M.,Lea, S.M.,Handford, P.A. A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition. Nat.Struct.Mol.Biol., 15:849-, 2008 Cited by PubMed: 18660822DOI: 10.1038/NSMB.1457 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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