2VJ0

Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex with an FXDNF peptide from amphiphysin1 and a WVXF peptide from synaptojanin P170

2VJ0 の概要

• エントリーDOI: 10.2210/pdb2vj0/pdb
• 関連するPDBエントリー: 1B9K 1GW5 1KY6 1KY7 1KYF 1KYU 1QTP 1QTS 1W80 2DNR
• 分子名称: AP-2 COMPLEX SUBUNIT ALPHA-2, SYNAPTOJANIN-1, AMPHIPHYSIN, ... (8 entities in total)
• 機能のキーワード: protein transport, cytoplasmic vesicle, alternative splicing, transport, coated pit, sh3 domain, endocytosis, alpha-adaptin, golgi apparatus, phosphorylation, ap2, synapse, membrane, cytoplasm, coiled coil, amphiphysin, cytoskeleton, synaptojanin, lipid-binding, cell junction
• 由来する生物種: MUS MUSCULUS (MOUSE); 詳細
• 細胞内の位置: Cell membrane: P17427; Cytoplasm (By similarity): O43426; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): O08838
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 30976.45

構造登録者

Ford, M.G.J.,Praefcke, G.J.K.,McMahon, H.T. (登録日: 2007-12-06, 公開日: 2007-12-25, 最終更新日: 2023-12-13)

• 主引用文献: Olesen, L.E.,Ford, M.G.J.,Schmid, E.M.,Vallis, Y.,Madan Babu, M.,Li, P.H.,Mills, I.G.,Mcmahon, H.T.,Praefcke, G.J.K.; Solitary and Repetitive Binding Motifs for the Ap2 Complex {Alpha}-Appendage in Amphiphysin and Other Accessory Proteins.; J.Biol.Chem., 283:5099-, 2008; PubMed: 17986441; DOI: 10.1074/JBC.M708621200

実験手法

X-RAY DIFFRACTION (1.6 Å)