2VJ0
Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex with an FXDNF peptide from amphiphysin1 and a WVXF peptide from synaptojanin P170
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AP-2 COMPLEX SUBUNIT ALPHA-2 | polymer | 250 | 28048.0 | 1 | UniProt (P17427) Pfam (PF02883) Pfam (PF02296) | MUS MUSCULUS (MOUSE) | ADAPTER-RELATED PROTEIN COMPLEX 2 ALPHA-2 SUBUNIT, ALPHA-ADAPTIN C, ADAPTOR PROTEIN COMPLEX AP-2 ALPHA-2 SUBUNIT, CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 ALPHA-C LARGE CHAIN, 100 KDA COATED VESICLE PROTEIN C, PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN ALPHA C SUBUNIT |
| 2 | B (P) | SYNAPTOJANIN-1 | polymer | 12 | 1465.5 | 1 | UniProt (O43426) | HOMO SAPIENS | SYNAPTIC INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE 1, SYNAPTOJANIN-1 P170 |
| 3 | C (Q) | AMPHIPHYSIN | polymer | 7 | 866.9 | 1 | UniProt (O08838) | RATTUS NORVEGICUS | AMPHIPHYSIN1 |
| 4 | D (A) | BENZAMIDINE | non-polymer | 120.2 | 1 | Chemie (BEN) | |||
| 5 | E (A) | DITHIANE DIOL | non-polymer | 152.2 | 1 | Chemie (DTD) | |||
| 6 | F, G, H (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | J, K, L (A, P, Q) | water | water | 18.0 | 343 | Chemie (HOH) |
Sequence modifications
A: 689 - 692 (PDB: 2VJ0)
A: 693 - 938 (UniProt: P17427)
A: 693 - 938 (UniProt: P17427)
| PDB | External Database | Details |
|---|---|---|
| Leu 694 | Val 694 | conflict |
| Ile 787 | Val 787 | conflict |
| Gly 889 | Val 889 | conflict |
| Ala 890 | Leu 890 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 30380.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 596.0 | |
| All* | Total formula weight | 30976.5 |
