2VIS

INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY

2VIS の概要

• エントリーDOI: 10.2210/pdb2vis/pdb
• 分子名称: IMMUNOGLOBULIN (IGG1, LAMBDA), HEMAGGLUTININ, ZINC ION, ... (5 entities in total)
• 機能のキーワード: complex (hemagglutinin-immunoglobulin), glycoprotein, complex (hemagglutinin-immunoglobulin) complex, complex (hemagglutinin/immunoglobulin)
• 由来する生物種: Influenza A virus (A/X-31(H3N2)); 詳細
• 細胞内の位置: Virion membrane; Single-pass type I membrane protein (Potential): P03437
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 77967.22

構造登録者

Bizebard, T.,Fleury, D.,Gigant, B.,Wharton, S.A.,Skehel, J.J.,Knossow, M. (登録日: 1997-12-22, 公開日: 1998-04-29, 最終更新日: 2024-10-30)

主引用文献

Fleury, D.,Wharton, S.A.,Skehel, J.J.,Knossow, M.,Bizebard, T.
Antigen distortion allows influenza virus to escape neutralization.
Nat.Struct.Biol., 5:119-123, 1998

PubMed Abstract: The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.

PubMed: 9461077
DOI: 10.1038/nsb0298-119

実験手法

X-RAY DIFFRACTION (3.25 Å)