2VGP

Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor

2VGP の概要

• エントリーDOI: 10.2210/pdb2vgp/pdb
• 関連するPDBエントリー: 2BFX 2BFY 2VGO
• 分子名称: SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, ... (4 entities in total)
• 機能のキーワード: nucleotide-binding, serine/threonine-protein kinase, atp-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule
• 由来する生物種: XENOPUS LAEVIS (AFRICAN CLAWED FROG); 詳細
• 細胞内の位置: Nucleus: Q6DE08; Chromosome, centromere: O13024
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77653.39

構造登録者

Andersen, C.B.,Wan, Y.,Chang, J.W.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Nallan, L.,Musacchio, A.,Gray, N.S. (登録日: 2007-11-15, 公開日: 2008-02-26, 最終更新日: 2024-11-13)

主引用文献

Andersen, C.B.,Wan, Y.,Chang, J.W.,Riggs, B.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Kwiatkowski, N.,Suzuki, M.,Nallan, L.,Heald, R.,Musacchio, A.,Gray, N.S.
Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
Acs Chem.Biol., 3:180-, 2008

PubMed Abstract: Aurora family kinases regulate important events during mitosis including centrosome maturation and separation, mitotic spindle assembly, and chromosome segregation. Misregulation of Aurora kinases due to genetic amplification and protein overexpression results in aneuploidy and may contribute to tumorigenesis. Here we report the discovery of new small molecule aminothiazole inhibitors of Aurora kinases with exceptional kinase selectivity and report a 1.7 A cocrystal structure with the Aurora B:INCENP complex from Xenopus laevis. The compounds recapitulate the hallmarks of Aurora kinase inhibition, including decreased histone H3 serine 10 phosphorylation, failure to complete cytokinesis, and endoreduplication.

PubMed: 18307303
DOI: 10.1021/CB700200W

実験手法

X-RAY DIFFRACTION (1.7 Å)