2VGP

Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor

2VGP の概要

• エントリーDOI: 10.2210/pdb2vgp/pdb
• 関連するPDBエントリー: 2BFX 2BFY 2VGO
• 分子名称: SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, ... (4 entities in total)
• 機能のキーワード: nucleotide-binding, serine/threonine-protein kinase, atp-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule
• 由来する生物種: XENOPUS LAEVIS (AFRICAN CLAWED FROG); 詳細
• 細胞内の位置: Nucleus: Q6DE08; Chromosome, centromere: O13024
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77653.39

構造登録者

Andersen, C.B.,Wan, Y.,Chang, J.W.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Nallan, L.,Musacchio, A.,Gray, N.S. (登録日: 2007-11-15, 公開日: 2008-02-26, 最終更新日: 2023-12-13)

• 主引用文献: Andersen, C.B.,Wan, Y.,Chang, J.W.,Riggs, B.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Kwiatkowski, N.,Suzuki, M.,Nallan, L.,Heald, R.,Musacchio, A.,Gray, N.S.; Discovery of Selective Aminothiazole Aurora Kinase Inhibitors; Acs Chem.Biol., 3:180-, 2008; PubMed: 18307303; DOI: 10.1021/CB700200W

実験手法

X-RAY DIFFRACTION (1.7 Å)