2VF3

Aquifex aeolicus IspE in complex with ligand

2VF3 の概要

• エントリーDOI: 10.2210/pdb2vf3/pdb
• 関連するPDBエントリー: 2V2Q 2V2V 2V2Y 2V2Z 2V34 2V8P
• 分子名称: 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ethyl {3-[4-amino-5-{3-[(cyclopropylsulfonyl)amino]prop-1-yn-1-yl}-2-oxopyrimidin-1(2H)-yl]oxetan-3-yl}acetate, PYROPHOSPHATE 2-, ... (6 entities in total)
• 機能のキーワード: ispe, kinase, aquifex, transferase, atp-binding, isoprene biosynthesis, non-mevalonate, nucleotide-binding
• 由来する生物種: AQUIFEX AEOLICUS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61746.09

構造登録者

Alphey, M.S.,Hunter, W.N. (登録日: 2007-10-30, 公開日: 2008-11-25, 最終更新日: 2024-05-08)

• 主引用文献: Hirsch, A.K.,Alphey, M.S.,Lauw, S.,Seet, M.,Barandun, L.,Eisenreich, W.,Rohdich, F.,Hunter, W.N.,Bacher, A.,Diederich, F.; Inhibitors of the Kinase Ispe: Structure-Activity Relationships and Co-Crystal Structure Analysis.; Org.Biomol.Chem., 6:2719-, 2008; PubMed: 18633530; DOI: 10.1039/B804375B

実験手法

X-RAY DIFFRACTION (2.2 Å)