2VES

Crystal Structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

2VES の概要

• エントリーDOI: 10.2210/pdb2ves/pdb
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide, ... (5 entities in total)
• 機能のキーワード: lpxc, hydrolase, bb-78485, antibiotics, deacetylase, lipid synthesis, metalloprotease, hydroxamic acid, gram-negative bacteria, lipopolysaccharide, lipid a biosynthesis
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 101351.28

構造登録者

Mochalkin, I.,Knafels, J.D. (登録日: 2007-10-26, 公開日: 2008-01-15, 最終更新日: 2023-12-13)

• 主引用文献: Mochalkin, I.,Knafels, J.D.,Lightle, S.; Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.; Protein Sci., 17:450-457, 2008; PubMed: 18287278; DOI: 10.1110/ps.073324108

実験手法

X-RAY DIFFRACTION (1.9 Å)