2VCQ
Complex structure of prostaglandin D2 synthase at 1.95A.
Summary for 2VCQ
Entry DOI | 10.2210/pdb2vcq/pdb |
Related | 1IYH 1IYI 1V40 |
Descriptor | GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole, ... (4 entities in total) |
Functional Keywords | prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O60760 |
Total number of polymer chains | 4 |
Total formula weight | 95346.27 |
Authors | Hohwy, M.,Spadola, L.,Lundquist, B.,von Wachenfeldt, K.,Persdotter, S.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Folmer, R.H.A.,Edman, K. (deposition date: 2007-09-26, release date: 2008-04-15, Last modification date: 2023-12-13) |
Primary citation | Hohwy, M.,Spadola, L.,Lundquist, B.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Nilsson, E.,Persdotter, S.,Von Wachenfeldt, K.,Folmer, R.H.A.,Edman, K. Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design. J.Med.Chem., 51:2178-, 2008 Cited by PubMed: 18341273DOI: 10.1021/JM701509K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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