2VBB

Isopenicillin N synthase with substrate analogue ACOMP (35minutes oxygen exposure)

Summary for 2VBB

• Entry DOI: 10.2210/pdb2vbb/pdb
• Related: 1BK0 1BLZ 1HB1 1HB2 1HB3 1HB4 1IPS 1OBN 1OC1 1ODM 1ODN 1QIQ 1QJE 1QJF 1UZW 1W03 1W04 1W05 1W06 1W3V 1W3X 2BJS 2BU9 2IVI 2IVJ 2JB4 2VAU 2VBD 2VBP 2VCM 2VE1
• Descriptor: ISOPENICILLIN N SYNTHETASE, N^6^-{(1R)-2-{[(1S,2R)-1-carboxy-2-hydroxy-2-(methylsulfanyl)ethyl]oxy}-1-[(oxidosulfanyl)methyl]-2-oxoethyl}-6-oxo-L-lysine, FE (II) ION, ... (6 entities in total)
• Functional Keywords: oxidoreductase, antibiotic biosynthesis, penicillin biosynthesis, iron, oxygenase, vitamin c, metal-binding, monocyclic intermediate, b-lactam antibiotic
• Biological source: EMERICELLA NIDULANS (ASPERGILLUS NIDULANS)
• Total number of polymer chains: 1
• Total formula weight: 38318.35

Authors

Ge, W.,Clifton, I.J.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J. (deposition date: 2007-09-07, release date: 2008-07-29, Last modification date: 2023-12-13)

• Primary citation: Ge, W.,Clifton, I.J.,Stok, J.E.,Adlington, R.M.,Baldwin, J.E.,Rutledge, P.J.; Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?; J.Am.Chem.Soc., 130:10096-, 2008; PubMed: 18620394; DOI: 10.1021/JA8005397

Experimental method

X-RAY DIFFRACTION (1.4 Å)