2V9J

Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP

2V9J の概要

• エントリーDOI: 10.2210/pdb2v9j/pdb
• 関連するPDBエントリー: 2F15 2V8Q 2V92
• 分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (7 entities in total)
• 機能のキーワード: atp-binding, polymorphism, metal-binding, serine/threonine-protein kinase, kinase, magnesium, cbs domain, transferase, sterol biosynthesis, steroid biosynthesis, fatty acid biosynthesis, cholesterol biosynthesis, lipid synthesis, phosphorylation, nucleotide-binding
• 由来する生物種: RATTUS NORVEGICUS (RAT); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 66520.90

構造登録者

Xiao, B.,Heath, R.,Saiu, P.,Leiper, F.C.,Leone, P.,Jing, C.,Walker, P.A.,Haire, L.,Eccleston, J.F.,Davis, C.T.,Martin, S.R.,Carling, D.,Gamblin, S.J. (登録日: 2007-08-23, 公開日: 2007-09-25, 最終更新日: 2023-12-13)

• 主引用文献: Xiao, B.,Heath, R.,Saiu, P.,Leiper, F.C.,Leone, P.,Jing, C.,Walker, P.A.,Haire, L.,Eccleston, J.F.,Davis, C.T.,Martin, S.R.,Carling, D.,Gamblin, S.J.; Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase; Nature, 449:496-, 2007; PubMed: 17851531; DOI: 10.1038/NATURE06161

実験手法

X-RAY DIFFRACTION (2.53 Å)