2V8E
Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand.
Summary for 2V8E
Entry DOI | 10.2210/pdb2v8e/pdb |
Related | 1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2JGW 2JGX 2UWN |
Related PRD ID | PRD_900013 |
Descriptor | COMPLEMENT FACTOR H, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | alternative splicing, sucrose octasulphate, age-related macular degeneration, sushi, secreted, factor h, complement, polymorphism, complement alternate pathway, immune system, disease mutation, glycosaminoglycan, glycoprotein, innate immunity, immune response |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Secreted: P08603 |
Total number of polymer chains | 1 |
Total formula weight | 22721.53 |
Authors | Prosser, B.E.,Johnson, S.,Roversi, P.,Herbert, A.P.,Blaum, B.S.,Tyrrell, J.,Jowitt, T.A.,Clark, S.J.,Tarelli, E.,Uhrin, D.,Barlow, P.N.,Sim, R.B.,Day, A.J.,Lea, S.M. (deposition date: 2007-08-07, release date: 2007-10-02, Last modification date: 2024-10-09) |
Primary citation | Prosser, B.E.,Johnson, S.,Roversi, P.,Herbert, A.P.,Blaum, B.S.,Tyrrell, J.,Jowitt, T.A.,Clark, S.J.,Tarelli, E.,Uhrin, D.,Barlow, P.N.,Sim, R.B.,Day, A.J.,Lea, S.M. Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med., 204:2277-, 2007 Cited by PubMed: 17893204DOI: 10.1084/JEM.20071069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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