2V61

Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin

Summary for 2V61

• Entry DOI: 10.2210/pdb2v61/pdb
• Related: 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60
• Descriptor: AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE, ... (4 entities in total)
• Functional Keywords: fad, membrane, safinamide, flavoprotein, human mao b structure, reversible inhibitor binding, mitochondrion, transmembrane, oxidoreductase, neuroprotection, parkinson's disease
• Biological source: HOMO SAPIENS
• Cellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• Total number of polymer chains: 2
• Total formula weight: 119906.12

Authors

Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A. (deposition date: 2007-07-13, release date: 2007-10-16, Last modification date: 2023-12-13)

• Primary citation: Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A.; Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.; J.Med.Chem., 50:5848-, 2007; PubMed: 17915852; DOI: 10.1021/JM070677Y

Experimental method

X-RAY DIFFRACTION (1.7 Å)