2V61
Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
Summary for 2V61
Entry DOI | 10.2210/pdb2v61/pdb |
Related | 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 |
Descriptor | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE, ... (4 entities in total) |
Functional Keywords | fad, membrane, safinamide, flavoprotein, human mao b structure, reversible inhibitor binding, mitochondrion, transmembrane, oxidoreductase, neuroprotection, parkinson's disease |
Biological source | HOMO SAPIENS |
Cellular location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338 |
Total number of polymer chains | 2 |
Total formula weight | 119906.12 |
Authors | Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A. (deposition date: 2007-07-13, release date: 2007-10-16, Last modification date: 2023-12-13) |
Primary citation | Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A. Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs. J.Med.Chem., 50:5848-, 2007 Cited by PubMed: 17915852DOI: 10.1021/JM070677Y PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)