2V5A

CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 3

2V5A の概要

• エントリーDOI: 10.2210/pdb2v5a/pdb
• 関連するPDBエントリー: 1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V59 2VR1
• 分子名称: BIOTIN CARBOXYLASE, 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: fatty acid biosynthesis, biotin carboxylase, nucleotide-binding, atp-binding, antibacterial, lipid synthesis, fas, ligase, biotin, bacterial, inhibitor
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99133.55

構造登録者

Mochalkin, I.,Miller, J.R. (登録日: 2008-10-02, 公開日: 2009-01-13, 最終更新日: 2023-12-13)

• 主引用文献: Miller, J.R.,Dunham, S.,Mochalkin, I.,Banotai, C.,Bowman, M.,Buist, S.,Dunkle, B.,Hanna, D.,Harwood, H.J.,Huband, M.D.,Karnovsky, A.,Kuhn, M.,Limberakis, C.,Liu, J.Y.,Mehrens, S.,Mueller, W.T.,Narasimhan, L.,Ogden, A.,Ohren, J.,Prasad, J.V.,Shelly, J.A.,Skerlos, L.,Sulavik, M.,Thomas, V.H.,Vanderroest, S.,Wang, L.,Wang, Z.,Whitton, A.,Zhu, T.,Stover, C.K.; A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore.; Proc.Natl.Acad.Sci.USA, 106:1737-, 2009; PubMed: 19164768; DOI: 10.1073/PNAS.0811275106

実験手法

X-RAY DIFFRACTION (2.31 Å)