2V13
Crystal Structure of Renin with Inhibitor 7
Summary for 2V13
Entry DOI | 10.2210/pdb2v13/pdb |
Related | 1BBS 1BIL 1BIM 1HRN 1PR7 1PR8 1RNE 1UHQ 2BKS 2BKT 2G20 2REN 2V0Z 2V10 2V11 2V12 2V16 |
Descriptor | RENIN, N-[(2R,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE (2 entities in total) |
Functional Keywords | glycoprotein, inhibitor-complex, aspartyl protease, zymogen, protease, hydrolase, polymorphism, alternative splicing, hydrolase(acid proteinase), cleavage on pair of basic residues |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37732.63 |
Authors | Rahuel, J.,Rasetti, V.,Maibaum, J.,Rueger, H.,Goschke, R.,Cohen, N.C.,Stutz, S.,Cumin, F.,Fuhrer, W.,Wood, J.M.,Grutter, M.G. (deposition date: 2007-05-21, release date: 2008-07-08, Last modification date: 2019-04-03) |
Primary citation | Rahuel, J.,Rasetti, V.,Maibaum, J.,Rueger, H.,Goschke, R.,Cohen, N.C.,Stutz, S.,Cumin, F.,Fuhrer, W.,Wood, J.M.,Grutter, M.G. Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7:493-, 2000 Cited by PubMed: 10903938DOI: 10.1016/S1074-5521(00)00134-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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