2UZS

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K)

2UZS の概要

• エントリーDOI: 10.2210/pdb2uzs/pdb
• 関連するPDBエントリー: 1H10 1UNP 1UNQ 1UNR 2UVM 2UZR
• 分子名称: RAC-alpha serine/threonine-protein kinase, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE (3 entities in total)
• 機能のキーワード: transferase, glycogen biosynthesis, translation regulation, nucleotide- binding, glycogen metabolism, atp-binding, sugar transport, nuclear protein, serine/threonine-protein kinase, transport, carbohydrate metabolism, kinase, apoptosis, phosphorylation, glucose metabolism
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15299.85

構造登録者

Carpten, J.D.,Faber, A.L.,Horn, C.,Donoho, G.P.,Briggs, S.L.,Robbins, C.M.,Hostetter, G.,Boguslawski, S.,Moses, T.Y.,Savage, S.,Uhlik, M.,Lin, A.,Du, J.,Qian, Y.W.,Zeckner, D.J.,Tucker-Kellogg, G.,Touchman, J.,Patel, K.,Mousses, S.,Bittner, M.,Schevitz, R.,Lai, M.H.,Blanchard, K.L.,Thomas, J.E. (登録日: 2007-05-01, 公開日: 2007-07-17, 最終更新日: 2023-12-13)

• 主引用文献: Carpten, J.D.,Faber, A.L.,Horn, C.,Donoho, G.P.,Briggs, S.L.,Robbins, C.M.,Hostetter, G.,Boguslawski, S.,Moses, T.Y.,Savage, S.,Uhlik, M.,Lin, A.,Du, J.,Qian, Y.W.,Zeckner, D.J.,Tucker-Kellogg, G.,Touchman, J.,Patel, K.,Mousses, S.,Bittner, M.,Schevitz, R.,Lai, M.H.,Blanchard, K.L.,Thomas, J.E.; A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.; Nature, 448:439-444, 2007; PubMed: 17611497; DOI: 10.1038/nature05933

実験手法

X-RAY DIFFRACTION (2.46 Å)