2UZS
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | RAC-alpha serine/threonine-protein kinase | polymer | 125 | 14799.8 | 1 | UniProt (P31749) Pfam (PF00169) In PDB | Homo sapiens (Human) | Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha |
| 2 | A | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | non-polymer | 500.1 | 1 | Chemie (4IP) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 1 - 123 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Ace -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Lys 17 | Glu 17 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14799.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 500.1 | |
| All* | Total formula weight | 15299.8 |
