Crystal structure of the human FOXO3a-DBD bound to DNA

Summary for 2UZK

DescriptorFORKHEAD BOX PROTEIN O3A, 5'-D(*CP*TP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*AP*G)-3', ... (4 entities in total)
Functional Keywordstranscription, transcription regulation, chromosomal rearrangement, activator, apoptosis, dna-binding, winged helix, proto-oncogene, forkhead transcription factors, nuclear protein, phosphorylation, dna-binding domain
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm, cytosol O43524
Total number of polymer chains6
Total molecular weight37919.43
Tsai, K.-L.,Sun, Y.-J.,Huang, C.-Y.,Yang, J.-Y.,Hung, M.-C.,Hsiao, C.-D. (deposition date: 2007-04-30, release date: 2008-05-13, Last modification date: 2013-05-22)
Primary citation
Tsai, K.-L.,Sun, Y.-J.,Huang, C.-Y.,Yang, J.-Y.,Hung, M.-C.,Hsiao, C.-D.
Crystal Structure of the Human Foxo3A-Dbd/DNA Complex Suggests the Effects of Post-Translational Modification.
Nucleic Acids Res., 35:6984-, 2007
PubMed: 17940099 (PDB entries with the same primary citation)
DOI: 10.1093/NAR/GKM703
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2716414.1%27.2%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution