2UZH

Mycobacterium smegmatis 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF)

Summary for 2UZH

• Entry DOI: 10.2210/pdb2uzh/pdb
• Descriptor: 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ... (9 entities in total)
• Functional Keywords: ispf, lyase, mycobacteria, complex with cdp, non-mevalonate pathway of isoprenoid biosynthesis
• Biological source: MYCOBACTERIUM SMEGMATIS
• Total number of polymer chains: 3
• Total formula weight: 52600.31

Authors

Buetow, L.,Brown, A.C.,Parish, T.,Hunter, W.N. (deposition date: 2007-04-27, release date: 2007-11-06, Last modification date: 2023-12-13)

Primary citation

Buetow, L.,Brown, A.C.,Parish, T.,Hunter, W.N.
The Structure of Mycobacteria 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase, an Essential Enzyme, Provides a Platform for Drug Discovery.
Bmc Struct.Biol., 7:68-, 2007

PubMed Abstract: The prevalence of tuberculosis, the prolonged and expensive treatment that this disease requires and an increase in drug resistance indicate an urgent need for new treatments. The 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid precursor biosynthesis is an attractive chemotherapeutic target because it occurs in many pathogens, including Mycobacterium tuberculosis, and is absent from humans. To underpin future drug development it is important to assess which enzymes in this biosynthetic pathway are essential in the actual pathogens and to characterize them.

PubMed: 17956607
DOI: 10.1186/1472-6807-7-68

Experimental method

X-RAY DIFFRACTION (2.2 Å)