2UZH

Mycobacterium smegmatis 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF)

2UZH の概要

• エントリーDOI: 10.2210/pdb2uzh/pdb
• 分子名称: 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ... (9 entities in total)
• 機能のキーワード: ispf, lyase, mycobacteria, complex with cdp, non-mevalonate pathway of isoprenoid biosynthesis
• 由来する生物種: MYCOBACTERIUM SMEGMATIS
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 52600.31

構造登録者

Buetow, L.,Brown, A.C.,Parish, T.,Hunter, W.N. (登録日: 2007-04-27, 公開日: 2007-11-06, 最終更新日: 2023-12-13)

主引用文献

Buetow, L.,Brown, A.C.,Parish, T.,Hunter, W.N.
The Structure of Mycobacteria 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase, an Essential Enzyme, Provides a Platform for Drug Discovery.
Bmc Struct.Biol., 7:68-, 2007

PubMed Abstract: The prevalence of tuberculosis, the prolonged and expensive treatment that this disease requires and an increase in drug resistance indicate an urgent need for new treatments. The 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid precursor biosynthesis is an attractive chemotherapeutic target because it occurs in many pathogens, including Mycobacterium tuberculosis, and is absent from humans. To underpin future drug development it is important to assess which enzymes in this biosynthetic pathway are essential in the actual pathogens and to characterize them.

PubMed: 17956607
DOI: 10.1186/1472-6807-7-68

実験手法

X-RAY DIFFRACTION (2.2 Å)