2UV3

Structure of the signal-regulatory protein (SIRP) alpha domain that binds CD47.

2UV3 の概要

• エントリーDOI: 10.2210/pdb2uv3/pdb
• 分子名称: TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: cd47-binding domain of sirp-alpha, receptor, membrane, sh3- binding, glycoprotein, transmembrane, phosphorylation, human sirp-alpha n terminal v domain, immunoglobulin domain, signal-regulatory protein alpha
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28805.98

構造登録者

Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N. (登録日: 2007-03-08, 公開日: 2007-03-27, 最終更新日: 2024-05-01)

• 主引用文献: Hatherley, D.,Harlos, K.,Dunlop, D.C.,Stuart, D.I.,Barclay, A.N.; The Structure of the Macrophage Signal Regulatory Protein Alpha (Sirpalpha) Inhibitory Receptor Reveals a Binding Face Reminiscent of that Used by T Cell Receptors.; J.Biol.Chem., 282:14567-, 2007; PubMed: 17369261; DOI: 10.1074/JBC.M611511200

実験手法

X-RAY DIFFRACTION (1.8 Å)