2TSC

STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE

2TSC の概要

• エントリーDOI: 10.2210/pdb2tsc/pdb
• 分子名称: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase (methyltransferase)
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A884
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62486.41

構造登録者

Montfort, W.R.,Stroud, R.M. (登録日: 1991-07-03, 公開日: 1991-10-15, 最終更新日: 2024-06-05)

• 主引用文献: Montfort, W.R.,Perry, K.M.,Fauman, E.B.,Finer-Moore, J.S.,Maley, G.F.,Hardy, L.,Maley, F.,Stroud, R.M.; Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.; Biochemistry, 29:6964-6977, 1990; PubMed: 2223754; DOI: 10.1021/bi00482a004

実験手法

X-RAY DIFFRACTION (1.97 Å)