2RVD

NMR STRUCTURE of A MUTANT OF CHIGNOLIN, CLN025

2RVD の概要

• エントリーDOI: 10.2210/pdb2rvd/pdb
• 関連するPDBエントリー: 1UAO 5AWL
• NMR情報: BMRB: 20009
• 分子名称: CLN025 (1 entity in total)
• 機能のキーワード: beta-hairpin, mini-protein, chignolin, de novo protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1294.32

構造登録者

Kato, Y.,Ishimura, M.,Honda, S. (登録日: 2015-07-14, 公開日: 2015-08-12, 最終更新日: 2024-05-15)

主引用文献

Honda, S.,Akiba, T.,Kato, Y.S.,Sawada, Y.,Sekijima, M.,Ishimura, M.,Ooishi, A.,Watanabe, H.,Odahara, T.,Harata, K.
Crystal structure of a ten-amino acid protein
J.Am.Chem.Soc., 130:15327-15331, 2008

PubMed Abstract: What is the smallest protein? This is actually not such a simple question to answer, because there is no established consensus among scientists as to the definition of a protein. We describe here a designed molecule consisting of only 10 amino acids. Despite its small size, its essential characteristics, revealed by its crystal structure, solution structure, thermal stability, free energy surface, and folding pathway network, are consistent with the properties of natural proteins. The existence of this kind of molecule deepens our understanding of proteins and impels us to define an "ideal protein" without inquiring whether the molecule actually occurs in nature.

PubMed: 18950166
DOI: 10.1021/ja8030533

実験手法

SOLUTION NMR