2RVD

NMR STRUCTURE of A MUTANT OF CHIGNOLIN, CLN025

Summary for 2RVD

• Entry DOI: 10.2210/pdb2rvd/pdb
• Related: 1UAO 5AWL
• NMR Information: BMRB: 20009
• Descriptor: CLN025 (1 entity in total)
• Functional Keywords: beta-hairpin, mini-protein, chignolin, de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 1294.32

Authors

Kato, Y.,Ishimura, M.,Honda, S. (deposition date: 2015-07-14, release date: 2015-08-12, Last modification date: 2024-05-15)

Primary citation

Honda, S.,Akiba, T.,Kato, Y.S.,Sawada, Y.,Sekijima, M.,Ishimura, M.,Ooishi, A.,Watanabe, H.,Odahara, T.,Harata, K.
Crystal structure of a ten-amino acid protein
J.Am.Chem.Soc., 130:15327-15331, 2008

PubMed Abstract: What is the smallest protein? This is actually not such a simple question to answer, because there is no established consensus among scientists as to the definition of a protein. We describe here a designed molecule consisting of only 10 amino acids. Despite its small size, its essential characteristics, revealed by its crystal structure, solution structure, thermal stability, free energy surface, and folding pathway network, are consistent with the properties of natural proteins. The existence of this kind of molecule deepens our understanding of proteins and impels us to define an "ideal protein" without inquiring whether the molecule actually occurs in nature.

PubMed: 18950166
DOI: 10.1021/ja8030533

Experimental method

SOLUTION NMR