2RL3

Crystal structure of the OXA-10 W154H mutant at pH 7

Summary for 2RL3

• Entry DOI: 10.2210/pdb2rl3/pdb
• Related: 1K4F 2HP5 2HP6 2HP9 2HPB
• Descriptor: Beta-lactamase PSE-2, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: oxa-10, carboxylated lysine, class d beta-lactamase, antibiotic resistance, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 56516.00

Authors

Vercheval, L.,Kerff, F.,Herman, R.,Sauvage, E.,Guiet, R.,Charlier, P.,Frere, J.-M.,Galleni, M. (deposition date: 2007-10-18, release date: 2008-10-28, Last modification date: 2023-11-15)

• Primary citation: Baurin, S.,Vercheval, L.,Bouillenne, F.,Falzone, C.,Brans, A.,Jacquamet, L.,Ferrer, J.L.,Sauvage, E.,Dehareng, D.,Frere, J.M.,Charlier, P.,Galleni, M.,Kerff, F.; Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.; Biochemistry, 48:11252-11263, 2009; PubMed: 19860471; DOI: 10.1021/bi901548c

Experimental method

X-RAY DIFFRACTION (1.9 Å)