2RKU

Structure of PLK1 in complex with BI2536

Summary for 2RKU

Entry DOI	10.2210/pdb2rku/pdb
Descriptor	Serine/threonine-protein kinase PLK1, ZINC ION, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ... (7 entities in total)
Functional Keywords	structure of plk1, selectivity residues, kinase, polo-like kinase, structure based drug design, atp-binding, nucleotide-binding, nucleus, phosphorylation, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P53350
Total number of polymer chains	1
Total formula weight	35160.96
Authors	Ding, Y.-H.,Kothe, M.,Kohls, D.,Low, S. (deposition date: 2007-10-17, release date: 2008-02-05, Last modification date: 2024-02-21)
Primary citation	Kothe, M.,Kohls, D.,Low, S.,Coli, R.,Rennie, G.R.,Feru, F.,Kuhn, C.,Ding, Y.-H. Selectivity-determining residues in Plk1. Chem.Biol.Drug Des., 70:540-546, 2007 Cited by PubMed: 18005335 DOI: 10.1111/j.1747-0285.2007.00594.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation