2RIW

The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine

Summary for 2RIW

• Entry DOI: 10.2210/pdb2riw/pdb
• Related: 2RIV
• Descriptor: Thyroxine-binding globulin, 3,5,3',5'-TETRAIODO-L-THYRONINE, ... (4 entities in total)
• Functional Keywords: thyroxine binding globulin, thyroxine, complex, serpin, tbg, disease mutation, glycoprotein, secreted, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P05543 P05543
• Total number of polymer chains: 2
• Total formula weight: 43269.80

Authors

Zhou, A.,Wei, Z.,Stanley, P.L.D.,Read, R.J.,Stein, P.E.,Carrell, R.W. (deposition date: 2007-10-12, release date: 2008-10-14, Last modification date: 2023-11-15)

• Primary citation: Qi, X.,Loiseau, F.,Chan, W.L.,Yan, Y.,Wei, Z.,Milroy, L.G.,Myers, R.M.,Ley, S.V.,Read, R.J.,Carrell, R.W.,Zhou, A.; Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins; J.Biol.Chem., 286:16163-16173, 2011; PubMed: 21325280; DOI: 10.1074/jbc.M110.171082

Experimental method

X-RAY DIFFRACTION (2.04 Å)