2RIV

Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin

Summary for 2RIV

• Entry DOI: 10.2210/pdb2riv/pdb
• Related: 2RIW
• Descriptor: Thyroxine-binding globulin, GLYCEROL, SULFATE ION, ... (5 entities in total)
• Functional Keywords: tbg, serpin, cleaved, thyroxine binding globulin, thyroxine, disease mutation, glycoprotein, secreted, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P05543 P05543
• Total number of polymer chains: 2
• Total formula weight: 43472.86

Authors

Zhou, A.,Wei, Z.,Stanley, P.L.D.,Read, R.J.,Stein, P.E.,Carrell, R.W. (deposition date: 2007-10-12, release date: 2008-10-14, Last modification date: 2023-10-25)

• Primary citation: Qi, X.,Loiseau, F.,Chan, W.L.,Yan, Y.,Wei, Z.,Milroy, L.G.,Myers, R.M.,Ley, S.V.,Read, R.J.,Carrell, R.W.,Zhou, A.; Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins; J.Biol.Chem., 286:16163-16173, 2011; PubMed: 21325280; DOI: 10.1074/jbc.M110.171082

Experimental method

X-RAY DIFFRACTION (1.5 Å)