2RIO

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation of non-conventional splicing

2RIO の概要

• エントリーDOI: 10.2210/pdb2rio/pdb
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, MAGNESIUM ION, STRONTIUM ION, ... (4 entities in total)
• 機能のキーワード: protein-nucleotide complex, atp-binding, endoplasmic reticulum, glycoprotein, hydrolase, kinase, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transcription, transcription regulation, transferase, transmembrane, unfolded protein response
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type I membrane protein: P32361
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 101155.05

構造登録者

Lee, K.P.,Dey, M.,Neculai, D.,Cao, C.,Dever, T.E.,Sicheri, F. (登録日: 2007-10-12, 公開日: 2008-01-29, 最終更新日: 2024-02-21)

• 主引用文献: Lee, K.P.,Dey, M.,Neculai, D.,Cao, C.,Dever, T.E.,Sicheri, F.; Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.; Cell(Cambridge,Mass.), 132:89-100, 2008; PubMed: 18191223; DOI: 10.1016/j.cell.2007.10.057

実験手法

X-RAY DIFFRACTION (2.4 Å)