2RH2
High Resolution DHFR R-67
Summary for 2RH2
| Entry DOI | 10.2210/pdb2rh2/pdb |
| Related | 2GQV |
| Descriptor | Dihydrofolate reductase type 2, (4R)-2-METHYLPENTANE-2,4-DIOL (3 entities in total) |
| Functional Keywords | folate metabolism, plasmid-encoded r67 dhfr, tmp-resistant dhfr, antibiotic resistance, methotrexate resistance, nadp, one-carbon metabolism, oxidoreductase, trimethoprim resistance |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 7205.22 |
| Authors | Krahn, J.M.,London, R.E. (deposition date: 2007-10-05, release date: 2008-06-03, Last modification date: 2023-08-30) |
| Primary citation | Krahn, J.M.,Jackson, M.R.,DeRose, E.F.,Howell, E.E.,London, R.E. Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex Biochemistry, 46:14878-14888, 2007 Cited by PubMed: 18052202DOI: 10.1021/bi701532r PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.96 Å) |
Structure validation
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