2RGP
Structure of EGFR in complex with hydrazone, a potent dual inhibitor
2RGP の概要
エントリーDOI | 10.2210/pdb2rgp/pdb |
分子名称 | Epidermal growth factor receptor, PHOSPHATE ION, N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]-5-[(piperidin-1-ylamino)methyl]pyrimidine-4,6-diamine, ... (4 entities in total) |
機能のキーワード | kinase domain, alternative splicing, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 36707.27 |
構造登録者 | |
主引用文献 | Xu, G.,Abad, M.C.,Connolly, P.J.,Neeper, M.P.,Struble, G.T.,Springer, B.A.,Emanuel, S.L.,Pandey, N.,Gruninger, R.H.,Adams, M.,Moreno-Mazza, S.,Fuentes-Pesquera, A.R.,Middleton, S.A. 4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors. Bioorg.Med.Chem.Lett., 18:4615-4619, 2008 Cited by PubMed: 18653333DOI: 10.1016/j.bmcl.2008.07.020 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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