2RFE

Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

2RFE の概要

• エントリーDOI: 10.2210/pdb2rfe/pdb
• 関連するPDBエントリー: 2RF9 2RFD
• 分子名称: Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1 (3 entities in total)
• 機能のキーワード: kinase domain, inhibition, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation, cytoplasm
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533; Cytoplasm : Q9UJM3
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 156370.83

構造登録者

Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J. (登録日: 2007-09-28, 公開日: 2007-12-04, 最終更新日: 2023-08-30)

• 主引用文献: Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J.; Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.; Nature, 450:741-744, 2007; PubMed: 18046415; DOI: 10.1038/nature05998

実験手法

X-RAY DIFFRACTION (2.9 Å)