2RF2
HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)
Summary for 2RF2
| Entry DOI | 10.2210/pdb2rf2/pdb |
| Descriptor | Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT), 5-bromo-3-(pyrrolidin-1-ylsulfonyl)-1H-indole-2-carboxamide, ... (4 entities in total) |
| Functional Keywords | hiv-1 revers transcriptase, ais, non-nucleoside inhibition, nucleotidyltransferase, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleus, phosphorylation, protease, rna-binding, rna-directed dna polymerase, viral nucleoprotein, virion, zinc, zinc-finger, transferase |
| Biological source | HIV-1 M:B_HXB2R More |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
| Total number of polymer chains | 2 |
| Total formula weight | 116998.97 |
| Authors | Yan, Y.,Prasad, S. (deposition date: 2007-09-27, release date: 2008-01-01, Last modification date: 2023-08-30) |
| Primary citation | Zhao, Z.,Wolkenberg, S.E.,Lu, M.,Munshi, V.,Moyer, G.,Feng, M.,Carella, A.V.,Ecto, L.T.,Gabryelski, L.J.,Lai, M.T.,Prasad, S.G.,Yan, Y.,McGaughey, G.B.,Miller, M.D.,Lindsley, C.W.,Hartman, G.D.,Vacca, J.P.,Williams, T.M. Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs). Bioorg.Med.Chem.Lett., 18:554-559, 2008 Cited by PubMed: 18083561DOI: 10.1016/j.bmcl.2007.11.085 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report
