2REW

Crystal Structure of PPARalpha ligand binding domain with BMS-631707

2REW の概要

• エントリーDOI: 10.2210/pdb2rew/pdb
• 分子名称: Peroxisome proliferator-activated receptor alpha, N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE, (2S,3S)-1-(4-METHOXYPHENYL)-3-(3-(2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY)BENZYL)-4-OXOAZETIDINE-2-CARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: alpha helical, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q07869
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32691.05

構造登録者

Muckelbauer, J. (登録日: 2007-09-27, 公開日: 2007-11-27, 最終更新日: 2024-04-03)

• 主引用文献: Wang, W.,Devasthale, P.,Farrelly, D.,Gu, L.,Peters, A.,Harrity, T.,Cap, M.,Chu, C.,Kunselman, L.,Morgan, N.,Ponticiello, R.,Zebo, R.,Zhang, L.,Locke, K.,Lippy, J.,O'Malley, K.,Hosagrahara, V.,Zhang, L.,Kadiyala, P.,Chang, C.Y.,Muckelbauer, J.,Zahler, R.,Hariharan, N.,Ryono, D.,Cheng, P.T.W.; Discovery of Azetidinone Acids as Conformationally-Constrained Dual (alpha/gamma) PPAR Activators; To be Published,

実験手法

X-RAY DIFFRACTION (2.35 Å)