2RB4

Crystal structure of the Helicase domain of human DDX25 RNA helicase

Replaces:  2G2J

Summary for 2RB4

• Entry DOI: 10.2210/pdb2rb4/pdb
• Descriptor: ATP-dependent RNA helicase DDX25, CHLORIDE ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: rna helicase, rossmann fold, structural genomics, structural genomics consortium, sgc, alternative initiation, atp-binding, developmental protein, differentiation, hydrolase, mrna transport, nucleotide-binding, nucleus, phosphorylation, rna-binding, spermatogenesis, translation regulation, transport
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9UHL0
• Total number of polymer chains: 2
• Total formula weight: 40660.72

Authors

Lehtio, L.,Hogbom, M.,Uppenberg, J.,Arrowsmith, C.H.,Berglund, H.,Edwards, A.M.,Ehn, M.,Flodin, S.,Flores, A.,Graslund, S.,Hallberg, B.M.,Hammarstrom, M.,Kotenyova, T.,Nilsson-Ehle, P.,Nordlund, P.,Nyman, T.,Ogg, D.,Persson, C.,Sagemark, J.,Stenmark, P.,Sundstrom, M.,Thorsell, A.G.,Van den Berg, S.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2007-09-18, release date: 2007-10-02, Last modification date: 2023-08-30)

• Primary citation: Schutz, P.,Karlberg, T.,van den Berg, S.,Collins, R.,Lehtio, L.,Hogbom, M.,Holmberg-Schiavone, L.,Tempel, W.,Park, H.W.,Hammarstrom, M.,Moche, M.,Thorsell, A.G.,Schuler, H.; Comparative Structural Analysis of Human DEAD-Box RNA Helicases.; Plos One, 5:12791-12791, 2010; PubMed: 20941364; DOI: 10.1371/journal.pone.0012791

Experimental method

X-RAY DIFFRACTION (2.8 Å)