2RA0

X-ray Structure of FXa in complex with 7-fluoroindazole

Summary for 2RA0

• Entry DOI: 10.2210/pdb2ra0/pdb
• Descriptor: Coagulation factor X, 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-7-fluoro-1H-indazole-3-carboxamide, ... (4 entities in total)
• Functional Keywords: serine protease, blood coagulation, calcium, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, polymorphism, zymogen
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32421.64

Authors

Abad, M.C. (deposition date: 2007-09-14, release date: 2008-01-29, Last modification date: 2021-10-20)

• Primary citation: Lee, Y.K.,Parks, D.J.,Lu, T.,Thieu, T.V.,Markotan, T.,Pan, W.,McComsey, D.F.,Milkiewicz, K.L.,Crysler, C.S.,Ninan, N.,Abad, M.C.,Giardino, E.C.,Maryanoff, B.E.,Damiano, B.P.,Player, M.R.; 7-fluoroindazoles as potent and selective inhibitors of factor xa.; J.Med.Chem., 51:282-297, 2008; PubMed: 18159923; DOI: 10.1021/jm701217r

Experimental method

X-RAY DIFFRACTION (2.3 Å)