2R9M

Cathepsin S complexed with Compound 15

2R9M の概要

• エントリーDOI: 10.2210/pdb2r9m/pdb
• 関連するPDBエントリー: 2R9N 2R9O
• 分子名称: Cathepsin S, N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide (3 entities in total)
• 機能のキーワード: hydrolase, cathepsin, protease, glycoprotein, lysosome, polymorphism, thiol protease, zymogen
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50206.41

構造登録者

Ward, Y.D.,Emmanuel, M.J.,Thomson, D.S.,Liu, W.,Bekkali, Y.,Frye, L.L.,Girardot, M.,Morwick, T.,Young, E.R.R.,Zindell, R.,Hrapchak, M.,DeTuri, M.,White, A.,Crane, K.M.,White, D.M.,Wang, Y.,Hao, M.-H.,Grygon, C.A.,Labadia, M.E.,Wildeson, J.,Freeman, D.,Nelson, R.,Capolino, A.,Peterson, J.D.,Raymond, E.L.,Brown, M.L.,Spero, D.M. (登録日: 2007-09-13, 公開日: 2007-12-18, 最終更新日: 2023-08-30)

• 主引用文献: Ward, Y.D.,Emmanuel, M.J.,Thomson, D.S.,Liu, W.,Bekkali, Y.,Frye, L.L.,Girardot, M.,Morwick, T.,Young, E.R.R.,Zindell, R.,Hrapchak, M.,DeTuri, M.,White, A.,Crane, K.M.,White, D.M.,Wang, Y.,Hao, M.-H.,Grygon, C.A.,Labadia, M.E.,Wildeson, J.,Freeman, D.,Nelson, R.,Capolino, A.,Peterson, J.D.,Raymond, E.L.,Brown, M.L.,Spero, D.M.; Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation; To be Published,

実験手法

X-RAY DIFFRACTION (1.97 Å)