2R6W

Estrogen receptor alpha ligand-binding domain complexed to a SERM

2R6W の概要

• エントリーDOI: 10.2210/pdb2r6w/pdb
• 関連するPDBエントリー: 2R6Y
• 分子名称: Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone (3 entities in total)
• 機能のキーワード: estrogen receptor, ligand-binding domain, alternative splicing, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, polymorphism, steroid-binding, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57569.56

構造登録者

Wang, Y. (登録日: 2007-09-06, 公開日: 2008-04-08, 最終更新日: 2023-08-30)

• 主引用文献: Dai, S.Y.,Chalmers, M.J.,Bruning, J.,Bramlett, K.S.,Osborne, H.E.,Montrose-Rafizadeh, C.,Barr, R.J.,Wang, Y.,Wang, M.,Burris, T.P.,Dodge, J.A.,Griffin, P.R.; Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.; Proc.Natl.Acad.Sci.Usa, 105:7171-7176, 2008; PubMed: 18474858; DOI: 10.1073/pnas.0710802105

実験手法

X-RAY DIFFRACTION (2 Å)