2R4F

Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors

2R4F の概要

• エントリーDOI: 10.2210/pdb2r4f/pdb
• 関連するPDBエントリー: 2Q1L 2Q6B 2Q6C 3BGL
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, (3R,5R)-7-[1-(4-fluorophenyl)-4-(1-methylethyl)-3-{methyl[(1R)-1-phenylethyl]carbamoyl}-1H-pyrazol-5-yl]-3,5-dihydroxyheptanoic acid, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, cholesterol, biocynthesis, hmg-coa, nadph, statin, alternative splicing, cholesterol biosynthesis, endoplasmic reticulum, glycoprotein, lipid synthesis, membrane, peroxisome, polymorphism, steroid biosynthesis, sterol biosynthesis, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 192404.90

構造登録者

Pavlovsky, A.,Pfefferkorn, J.A.,Harris, M.S.,Finzel, B.C. (登録日: 2007-08-31, 公開日: 2008-04-29, 最終更新日: 2024-02-21)

• 主引用文献: Pfefferkorn, J.A.,Choi, C.,Larsen, S.D.,Auerbach, B.,Hutchings, R.,Park, W.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.H.,Robertson, A.,Sekerke, C.,Harris, M.S.,Pavlovsky, A.,Bainbridge, G.,Caspers, N.,Kowala, M.,Tait, B.D.; Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.; J.Med.Chem., 51:31-45, 2008; PubMed: 18072721; DOI: 10.1021/jm070849r

実験手法

X-RAY DIFFRACTION (1.7 Å)