2R3V

The Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

Summary for 2R3V

Entry DOI	10.2210/pdb2r3v/pdb
Descriptor	Mevalonate kinase (2 entities in total)
Functional Keywords	mevalonate kinase, farnesyl thiodiphophate, atp-binding, cataract, cholesterol biosynthesis, cytoplasm, disease mutation, lipid synthesis, nucleotide-binding, peroxisome, polymorphism, steroid biosynthesis, sterol biosynthesis, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q03426
Total number of polymer chains	4
Total formula weight	169991.05
Authors	Fu, Z.,Voynova, N.E.,Miziorko, H.M.,Kim, J.P. (deposition date: 2007-08-30, release date: 2008-06-24, Last modification date: 2023-08-30)
Primary citation	Fu, Z.,Voynova, N.E.,Herdendorf, T.J.,Miziorko, H.M.,Kim, J.J. Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism. Biochemistry, 47:3715-3724, 2008 Cited by PubMed: 18302342 DOI: 10.1021/bi7024386 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation