2R2U

Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment

2R2U の概要

• エントリーDOI: 10.2210/pdb2r2u/pdb
• 関連するPDBエントリー: 2R2R 2R2S 2R2T
• 分子名称: DNA (5'-D(*DAP*DTP*DTP*DTP*DAP*DGP*DT)-3'), DNA (5'-D(P*DTP*DAP*DCP*DTP*DAP*DAP*DAP*DT)-3'), Reverse transcriptase, ... (5 entities in total)
• 機能のキーワード: bleomycin, drug-dna complex, protein-dna complex, mmlv rt, aspartyl protease, dna integration, dna recombination, endonuclease, hydrolase, multifunctional enzyme, nuclease, nucleotidyltransferase, protease, rna-directed dna polymerase, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Moloney murine leukemia virus (MoMLV)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p15: Virion . Capsid protein p30: Virion . Nucleocapsid protein p10: Virion : P03355
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 33795.78

構造登録者

Goodwin, K.D.,Lewis, M.A.,Long, E.C.,Georgiadis, M.M. (登録日: 2007-08-27, 公開日: 2008-07-22, 最終更新日: 2023-08-30)

• 主引用文献: Goodwin, K.D.,Lewis, M.A.,Long, E.C.,Georgiadis, M.M.; Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.; Proc.Natl.Acad.Sci.Usa, 105:5052-5056, 2008; PubMed: 18362349; DOI: 10.1073/pnas.0708143105

実験手法

X-RAY DIFFRACTION (2.3 Å)