2R2L

Structure of Farnesyl Protein Transferase bound to PB-93

2R2L の概要

• エントリーDOI: 10.2210/pdb2r2l/pdb
• 分子名称: Farnesyltransferase subunit alpha, Farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total)
• 機能のキーワード: malaria, fpt, transferase, metal-binding, phosphorylation, prenyltransferase, zinc
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83807.27

構造登録者

Strickland, C.O.,Voorhis, W. (登録日: 2007-08-27, 公開日: 2008-03-11, 最終更新日: 2024-02-21)

• 主引用文献: Van Voorhis, W.C.,Rivas, K.L.,Bendale, P.,Nallan, L.,Horney, C.,Barrett, L.K.,Bauer, K.D.,Smart, B.P.,Ankala, S.,Hucke, O.,Verlinde, C.L.,Chakrabarti, D.,Strickland, C.,Yokoyama, K.,Buckner, F.S.,Hamilton, A.D.,Williams, D.K.,Lombardo, L.J.,Floyd, D.,Gelb, M.H.; Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.; Antimicrob.Agents Chemother., 51:3659-3671, 2007; PubMed: 17606674; DOI: 10.1128/AAC.00246-07

実験手法

X-RAY DIFFRACTION (2.23 Å)