2R0O
Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E)
Summary for 2R0O
Entry DOI | 10.2210/pdb2r0o/pdb |
Descriptor | Alpha-actinin-4, GLYCEROL (3 entities in total) |
Functional Keywords | calponin homology domain, ch domain, structural protein, actin-binding protein, actin-crosslinking, glomeruloscleros spectrin family, disease mutation, nucleus, phosphorylation |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O43707 |
Total number of polymer chains | 2 |
Total formula weight | 54624.50 |
Authors | Lee, S.H.,Dominguez, R. (deposition date: 2007-08-20, release date: 2008-02-05, Last modification date: 2024-03-13) |
Primary citation | Lee, S.H.,Weins, A.,Hayes, D.B.,Pollak, M.R.,Dominguez, R. Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J.Mol.Biol., 376:317-324, 2008 Cited by PubMed: 18164029DOI: 10.1016/j.jmb.2007.11.084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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