2R0O
Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Alpha-actinin-4 | polymer | 237 | 27128.1 | 2 | UniProt (O43707) Pfam (PF00307) | Homo sapiens (human) | Non-muscle alpha-actinin 4, F-actin cross-linking protein |
| 2 | C, D, E, F (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | Non-muscle alpha-actinin 4, F-actin cross-linking protein | ||
| 3 | G, H (A, B) | water | water | 18.0 | 457 | Chemie (HOH) |
Sequence modifications
A, B: 47 - 271 (UniProt: O43707)
| PDB | External Database | Details |
|---|---|---|
| Gly 40 | - | expression tag |
| Ala 41 | - | expression tag |
| Met 42 | - | expression tag |
| Asp 43 | - | expression tag |
| Pro 44 | - | expression tag |
| Glu 45 | - | expression tag |
| Phe 46 | - | expression tag |
| Glu 255 | Lys 255 | engineered mutation |
| Leu 272 | - | expression tag |
| Asp 273 | - | expression tag |
| Glu 274 | - | expression tag |
| Leu 275 | - | expression tag |
| Asn 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54256.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 368.4 | |
| All* | Total formula weight | 54624.5 |
