2R0O

Crystal structure of the actin-binding domain of human alpha-actinin-4 mutant(K255E)

Summary for 2R0O

Entry DOI	10.2210/pdb2r0o/pdb
Descriptor	Alpha-actinin-4, GLYCEROL (3 entities in total)
Functional Keywords	calponin homology domain, ch domain, structural protein, actin-binding protein, actin-crosslinking, glomeruloscleros spectrin family, disease mutation, nucleus, phosphorylation
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O43707
Total number of polymer chains	2
Total formula weight	54624.50
Authors	Lee, S.H.,Dominguez, R. (deposition date: 2007-08-20, release date: 2008-02-05, Last modification date: 2024-03-13)
Primary citation	Lee, S.H.,Weins, A.,Hayes, D.B.,Pollak, M.R.,Dominguez, R. Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J.Mol.Biol., 376:317-324, 2008 Cited by PubMed: 18164029 DOI: 10.1016/j.jmb.2007.11.084 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation