2R05

Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain

Summary for 2R05

• Entry DOI: 10.2210/pdb2r05/pdb
• Related: 2R02 2R03
• Descriptor: Programmed cell death 6-interacting protein, p6-Gag (3 entities in total)
• Functional Keywords: coiled-coil, apoptosis, cytoplasm, host-virus interaction, polymorphism, protein transport, transport, aids, capsid protein, lipoprotein, membrane, metal-binding, myristate, nucleus, phosphorylation, rna-binding, viral nucleoprotein, virion, zinc, zinc-finger
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytosol : Q8WUM4; Gag polyprotein: Host cell membrane ; Lipid-anchor . Matrix protein p17: Virion membrane ; Lipid-anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion : P35962
• Total number of polymer chains: 2
• Total formula weight: 79337.14

Authors

Hill, C.P.,Zhai, Q.,Fisher, R.D. (deposition date: 2007-08-17, release date: 2007-12-18, Last modification date: 2024-02-21)

• Primary citation: Zhai, Q.,Fisher, R.D.,Chung, H.Y.,Myszka, D.G.,Sundquist, W.I.,Hill, C.P.; Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV.; Nat.Struct.Mol.Biol., 15:43-49, 2008; PubMed: 18066081; DOI: 10.1038/nsmb1319

Experimental method

X-RAY DIFFRACTION (2.55 Å)