2QYN
Crystal structure of PDE4D2 in complex with inhibitor NPV
Summary for 2QYN
Entry DOI | 10.2210/pdb2qyn/pdb |
Related | 2qyk 2qyl 2qym |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, ZINC ION, ... (5 entities in total) |
Functional Keywords | pde4d selective inhibitor nvp, alternative splicing, camp, cytoplasm, cytoskeleton, hydrolase, membrane, metal-binding, phosphorylation |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q08499 |
Total number of polymer chains | 2 |
Total formula weight | 76509.73 |
Authors | |
Primary citation | Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408:193-201, 2007 Cited by PubMed: 17727341DOI: 10.1042/BJ20070970 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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